梦想者的家园

   

   实验室倡导“快乐科学 (Happy Science)” 理念,以兴趣为导向,基础理论研究和应用实践相结合,欢迎有志于植物科学研究的优秀研究生加入团队,实验室常年招收有梦想的博士后、客座进修人员。我们的理念 “building a stage for each dreamer!

   研究生招生及博士后申请参照中科院遗传发育所 研究生招生博士后申请。如需了解实验室详情,请访问实验室网站 Chulab,阅读实验室发表文章全文请访问 ResearchGate-Chengcai Chu

  Right Here Waiting......

研究组主要以水稻为研究材料,开展农作物源库互作和产量构成、种子休眠和萌发等分子机制,并利用分子手段实现对植物基因表达的精细调控和作物品种的分子设计改良等研究。主要研究内容:

1水稻氮肥高效利用分子机制的解析

氮素是植物需求量最大的矿质营养元素,也是作物增产最重要的促进因子之一。然而大量氮肥的施用导致土壤酸化及水体富营养化等环境污染,同时,不断增长的人口对粮食产量又提出了更严峻的挑战。因此,提高作物氮利用效率是实现农业可持续发展的重要措施

我们研究表明,硝酸盐转运蛋白基因NRT1.1B/OsNPF6.5在籼稻与粳稻间呈现显著分化,且籼稻型NRT1.1B在水稻驯化过程中受到人工选择。将NRT1.1B-indica导入到粳稻品种,可显著提高粳稻产量及氮肥利用效率。这些结果表明,NRT1.1B的自然变异是导致籼粳稻氮肥利用效率差异的重要原因。这一结果不仅揭示了水稻籼粳亚种间氮肥利用差异的分子机制,也为提高粳稻氮利用效率提供了一个重要基因位点。进一步揭示水稻氮肥利用效率的分子机制,解析氮信号转导的调控网络是实验室的重要研究内容。

2、水稻源库互作和产量构成

作物产量的生理基础实质上是源-库关系的协调。课题组收集了大量水稻源供给能力(叶光合能力等)和库强度(籽粒大小及饱满度等)发生改变的种质资源,并进行相关基因的克隆和鉴定,以期对水稻源-库关系,特别是叶片早衰和种子发育调控机制进行系统解析。

       在农业生产上,早衰导致作物叶片过早丧失光合同化能力,减少籽粒干物质积累,从而影响农作物的产量和品质。我们分离鉴定到一个显性早衰突变体prematurely senile 1 (ps1-D)PS1编码一个NAC类转录激活子,OsNAP。研究表明,OsNAP显著受ABA诱导,并直接调控叶绿素降解(CDGs)和营养再转运(NTGs)等衰老相关基因(SAGs)的表达,我们下一步工作是以OsNAP为切入点,构建植物叶片衰老调控的分子遗传网络。

种子大小在很大程度上决定了库的大小,从而决定了作物产量,因此也是遗传育种的主要目标。我们发现,油菜素内酯(BR)对种子大小具有重要而特异的调控作用,这一特异作用主要是通过BR信号核心负调控子GSK2激酶的特异性底物来介导。因此,课题组通过多种手段对GSK2激酶底物进行了大规模鉴定,结合已鉴定出的多个受BR调控的粒重关键基因,以期建立粒重相关基因间的调控网络,促进对水稻籽粒发育调控分子机制的理解。

3、种子休眠和萌发的分子机制

禾谷类作物的休眠和萌发涉及到种子发育及与环境的互作,是一个极其复杂的农艺性状。小麦、水稻等禾谷类作物穗发芽现象严重影响了作物的产量和品质,但禾谷类种子休眠和萌发的分子机制目前仍无系统深入的研究。我们组通过对突变体的系统筛选,获得一系列影响水稻种子萌发的突变体,并已对多个控制穗发芽性状的基因进行了克隆和功能鉴定。我们希望通过对不同类型的休眠和萌发突变体的详细分析,阐明水稻休眠和萌发的分子机制。同时,我们通过筛选获得多个具不同休眠程度的自然变异材料及栽培品种,利用已有QTL结果和从突变体研究中获得的数据,认识人工驯化过程中种子休眠性降低的原因,为农作物的改良奠定基础。

4、作物品种的分子设计

随着基因组学研究的深入,利用已获得的知识和资源,有针对性对农作物进行分子设计改良也是课题组的重要研究内容之一。

课题组主要针对我国东北、长江中下游等地区粳稻生产所面临的重大需求,利用野生种、农家种等种质资源,在解析高产、稳产、优质和高效等复杂性状形成的关键调控位点及调控网络的同时,筛选相关基因的优异等位变异,通过全基因组选择技术加以聚合,建立了分子模块设计育种技术体系。目前,已和育种单位合作,培育出秀水114、秀水134等设计型水稻新品种2个,累计推广面积1200万亩。


The ChuLab mainly focuses on functional genomics and Agrobiotechnology by the use of rice as a model system. Besides tremendous efforts on germplasm collection, generation and screening of mutant population in last decades, the germplasms and mutants involved in agronomically important traits related to the plant architecture, source supply, and sink capacity, etc have been characterized, to dissect the molecular basis for rice yield improvement. Besides functional characterization of rice genes, we also make significant effort on Agrobiotechnology by using the knowledge, resources and tools obtained from our studies and combine approaches of genetics, molecular technologies, such as marker-assisted selection to improve complex agronomic traits. We are particularly interested in leaf senescence, grain size, nutrient use efficiency, the key agronomic traits in rice production. 


1986年安徽师范大学生物学学士。

1989年中国科学院植物研究所植物学硕士。

1993年赴德国国家植物遗传和作物育种研究所(IPK)从事甘氨酸脱羧酶基因和启动子的分离研究。

1996年德国Martin-Luther大学博士。

1997-1998德国植物遗传和作物育种研究所(IPK)博士后。

2011 中国科学院联想学院科技成果转移转化与规模产业化第九期研修班结业。

  • 1989.07-1993.05 河南师范大学生物系 讲师、助教

  • 1997.01-1998.12 德国植物遗传与作物育种研究所(IPK) 博士后

  • 1999.01-              中国科学院遗传与发育生物学研究所 研究员

教育体会:毕业于安徽师范大学,曾在河南师范大学学习工作7年,有11年师范大学学习、工作经历及17年培养硕士、博士研究生经历,在与学生沟通交流与教育方面有着丰富的经验和深刻的体会,主张Happy Science教育理念,获得研究人员和学生广泛认可,多次受邀到中国科学院、军事医学科学院、中国科学院大学、中国科技大学、兰州大学、四川大学、四川农业大学、扬州大学、安徽农业大学、河南农业大学、安徽师范大学、北京农学院等科研机构及高校给大学生、研究生及青年教师分享教学体会。

科学成就:长期以来一直从事植物基因表达的精细调控、农作物产量性状改良的分子基础及作物品种的分子设计研究,成功分离叶肉细胞、根、维管束鞘组织特异性启动子,在水稻营养高效吸收利用、种子大小和叶片衰老调控的分子机制,作物分子设计育种等基础及应用基础研究领域均做出了一系列原创性研究,为新一代水稻及其它作物高产育种改良提供了全新的思路。回国后已在 Nature Genetics, Nature Plants, PNAS, Plant Cell, New Phytologist, PLoS Genetics, Molecular Plant, Plant Physiology, Plant Journal等国际刊物发表论文112篇(SCI总影响因子553,他引 5199 次,h指数 40),申请专利40 多项,其中国际专利8项,与育种单位合作培育水稻新品种3个,其中秀水114、秀水134 2010年双双进入农业部万亩高产示范片,“高产优质多抗晚粳稻秀水134的选育和推广荣获2013年浙江嘉兴市科学技术进步一等奖,高产抗条纹叶枯病晚粳稻品种的选育和推广荣获2014年浙江省科学技术进步二等奖,“高产优质多抗晚粳稻秀水134的选育和推广 荣获2015年浙江省科学技术进步二等奖,秀水1342014年农业部推荐的30个水稻主导品种之一,秀水114和秀水134累积推广面积1200多万亩。

1999年获中国科学院王宽诚科研奖;

1999年入选中国科学院百人计划,引进国外杰出人才;

2004年入选首批新世纪百千万人才工程国家级人选;

2006年经国务院批准享受政府特殊津贴专家;

2008年获国家杰出青年基金;

2011年获益海嘉里优秀导师奖;

2013年“高产优质多抗晚粳稻秀水134的选育与推广”获2013年嘉兴市科学技术进步一等奖;

2014年“高产抗条纹叶枯病晚粳稻品种的选育与推广”获2014年浙江省科学技术进步二等奖;

2015年“高产优质多抗晚粳稻秀水134的选育和推广2015年浙江省科学技术进步二等奖;

2015年“组蛋白甲基化和小分子RNA调控植物生长发育的分子机理研究”获2015年北京市科学技术进步二等奖;

2015年荣获中国科学院遗传与发育生物学研究所优秀团队奖;

2016年荣获“第七届全国优秀科技工作者”光荣称号;

2016年入选中国科学院“特聘核心骨干”研究员;

2016 “水稻功能基因组和农业生物技术改良”创新团队荣获“第六届中国侨界贡献奖”。

  1. Brassinosteroid regulates gibberellin synthesis to promote cell elongation in rice: Critical comments on Ross and Quittenden’s letter
    Tong H and Chu C. Plant Cell: 2016 ,28(4) ,833-835
  2. Rice HOX12 regulates panicle exsertion by directly modulating the expression of ELONGATED UPPERMOST INTERNODE1
    Gao S, Fang J, Xu F, Wang W, Chu C. Plant Cell: 2016 ,28(3) ,680-695
  3. Control of grain size and rice yield by GL2-mediated brassinosteroid responses
    Che R, Tong H, Shi B, Liu Y, Fang S, Liu D, Xiao Y, Hu B, Liu L, Wang H, Zhao M, Chu C. Nature Plants: 2015 ,2 ,15195.
  4. Activation of Big Grain1 significantly imroves grain size by regulating auxin transport in rice
    Liu L^, Tong H^, Xiao Y, Che R, Xu F, Hu B, Liang C, Chu J, Li J, Chu C. Proc. Natl. Acad. Sci. USA: 2015 ,112(35) ,11102-11107
  5. Variation in NRT1.1B contributes to nitrate-use divergence between rice subspecies
    Hu B, Wang W, Ou S, Tang J, Li H, Che R, Zhang Z, Chai X, Wang H, Wang Y, Liang C, Liu L, Piao Z, Deng Q, Deng K, Xu C, Liang Y, Zhang L, Li L, Chu C. Nature Genetics: 2015 ,47(7) ,834-838
  6. Brassinosteroid regulates cell elongation by modulating gibberellin metabolism in rice
    Tong H, Xiao Y, Liu D, Gao S, Liu L, Yin Y, Jin Y, Qian Q, Chu C (2014). Plant Cell: 2014 ,26(11) ,4376-4393
  7. OsNAP connects absisic acid and leaf senescence by fine tuning absisic acid biosynthesis and directly targeting senescence-associated genes in rice
    Liang C, Wang Y, Zhu Y, Tang J, Hu B, Liu L, Ou S, Wu H, Sun X, Chu J, and Chu C. Proc. Natl. Acad. Sci. USA: 2014 ,111(27) ,10013-10018
  8. The histone methyltransferase SDG724 mediates H3K36me2/3 deposition at MADS50 and RFT1, and promotes flowering in rice
    Sun C, Fang J, Zhao T, Xu B, Zhang F, Liu L, Tang J, Zhang G, Deng X, Chen F, Qian Q, Cao X, Chu C. Plant Cell: 2012 ,24(8) ,3235-3247
  9. SDG714, a histone H3K9 methyltransferase, is involved in Tos17 DNA methylation and transposition in rice
    Ding Y, Wang X, Su L, Zhai J, Cao S, Zhang D, Liu C, Bi Y, Qian Q, Cheng Z, Chu C*, Cao X*. Plant Cell: 2007 ,19(1) ,9-22
  10. DWARF AND LOW-TILLERING acts as a direct downstream target of a GSK3/SHAGGY-like kinase to mediate brassinosteroid responses in rice
    Tong H, Liu L, Jin Y, Du L, Yin Y, Qian Q, Zhu L, Chu C. Plant Cell: 2012 ,24(6) ,2562–2577
  11. Insights into salt tolerance from the genome of Thellungiella salsuginea
    Wu HJ, Zhang Z, Wang JY, Oh DH, Sun HX, Wu Y, ...Liu Y, Zhang W, Zhang H, Chu J, Yan C, Fang S, Zhang J, Wang Y, Zhang F, Wang G, Lee SY, Cheeseman JM, Yang B, Li B, Min J, Yang L, Wang J*, Chu C*, Chen SY*, Bohnert HJ*, Zhu J-K*, Wang XJ*, Xie Q*. Proc. Natl. Acad. Sci. USA: 2012 ,109(30) ,: 12219-12224
  12. A rice plastidial nucleotide sugar epimerase is involved in galactolipid biosynthesis and improves photosynthetic efficiency
    Li C, Wang Y, Liu L, Hu Y, Zhang F, Sodmergen, Wang G, Schläppi MR, Chu C. PLoS Genetics: 2011 ,7(7) ,e1002196

1.       2006年3月22-24日, Edinburgh, “Modern biology and its socialimpact” hosted by  the ESRC Genomics Policy and Research Forum. Invited speaker: Agrobiotechnology, the driving force for the next green revolution in China

2.       2011年9月16-19日,广西南宁,植物分子生物学研讨会,专题报告。A Rice Plastidial Nucleotide Sugar Epimerase Is Involved in Galactolipid Biosynthesis and Improves Photosynthetic Efficiency.

3.       2011921-23, 保加利亚,Sunny Day Black Sea resort, Molecular Basis of Plant Stress. Invited Speaker. OsMT1a, Encoding a Type 1 Metallothionein, Plays the Pivotal Role in Zinc Homeostasis and Drought Tolerance in Rice.

4.       2011927-28, 北京Invited Speaker. The 6th Syngenta International Conference. The Future of Food ---From Biotechnology Point of View.

5.       20111018-20日,四川成都,中国作物学会50周年庆祝会暨2011年学术年会,特邀报告。水稻重要基因的挖掘与功能分析。

6.       2011111-5日,福建福州, 第三届全国植物生物技术及其产业化大会, 现代植物生物技术及其产业化应用. 专题报告。PHD1, Encoding A Novel Plastidial Nucleotide Sugar Epimerase, Is Essential for Galactolipid Biosynthesis in Rice.

7.       201267-8日,云南昆明,2012中国遗传学会大会。特邀报告,水稻功能基因的挖掘和鉴定。

8.       20121010-12日,陕西杨凌,全国植物基因组学大会从植物科学到农业生产专题报告。LVP1/SDG724 Acts as a Switch from Vegetative to Floral Development in Rice under Long-day Conditions.

9.       201385,美国Berkeley,邀请报告:Rice Genetics: From Genomes to Function.

10.    2014522-28日,中国上海,Sino-German Symposium on Metabolomics and Plant Development. 特邀报告人,Plastidial Nucleotide Sugar Epimerase Is a Potential Target for Rice Yield Improvement.

11.    201461-2日,澳大利亚,Canberra.CAS-CSIRO Workshop “Improving Photosynthesis and Yield Potential in Cereal Crops: Modelling, Mechanisms and Methods”. 特邀报告人。Rice Genetics: from Genomes to the Function

12.    201485-8, 中国贵阳,中国植物生理与植物分子生物学学会第十一届会员代表大会及全国学术年会。专题报告。OsNAP Acts as a Linker Between ABA and Leaf Senescence.

13.    2014109-10日,日本,Tsukuba. Joint workshop on plant research between IGDB and NIAS,特邀报告,Plant Senescence, Learning Something More.

14.    20141018-19日,安徽屯溪,全国农业生物化学与分子生物学第十三次学术研讨会暨中国生物化学与分子生物学会农业分会第三届全国代表大会. 特邀报告, OsNAP Plays a Pivotal Role in Regulating Leaf Senescence in Rice

15.    201536-7日,中国北京,Cereals,Biomass and Biofuels,特邀报告,Towards Understanding ABA-Mediated Leaf Senescence.

16.    2015519-22日,湖北武汉,第二届国际油菜素内酯大会(BR2015)。特邀报告,Mechanisms Underlying Brassinosteroid Regulating Plant Growth and Seed Development In Rice.

17.    2015616-18日,中国北京,PRSIS2015,特邀报告,Natural Variation in NRT1.1B Contributes to Nitrate Use Divergence between Indica and Japonica Subspecies of Rice.

18.    2015621-26日,Potsdam-Golm, Germany, Second Sino-German symposium on Metabolomics and Plant Development. 特邀报告,Nitrogen Use Efficiency: Transport Solution in Rice Variations.

19.    2015814-17日,云南昆明,遗传多样性:前沿与挑战,2015中国遗传学会大会。特邀报告,能否让粳稻具有籼稻一样氮肥利用效率?

20.    2015817-19日,西安杨凌,第六届全国小麦基因组学及分子育种大会。特邀报告,水稻遗传学:从实验室到田间。

21.    2015819-22日,西安杨凌,Plant Genomics in China XVI,特邀报告:Nitrogen-Use Efficiency: Transport Solution in Rice Variations.

22.    2015828-30日,湖北武汉,长江流域杂交水稻发展战略论坛,特邀报告:水稻生物技术改良: 从实验室理论到田间实践

23.    2015916-18日,安徽芜湖,生命与健康高端论坛,特邀报告:水稻遗传学: 从实验室理论到田间实践。

24.   2015921-24日,湖北武汉,13th Internaltional Symposium of Rice Functional Genomics (13th ISRFG), Rice Genome & Technology:  Feeding the Billions. 特邀报告:Natural variation in NRT1.1B contributes to nitrate use divergence between indica and japonica subspecies ofrice.

25.   20151021-22日,广东深圳,2015“大科普”跨界科学传播研讨会。特邀报告:粮食安全与转基因食品安全。

26.    20151116-18日,广东深圳,第二届国际农业基因组大会. 特邀报告:Rice Genetics: From Mechanisms to Breeding.

27.    201618-13, San Diego, USA, Plant and Animal Genome XXIV Conference. 特邀报告,Nitrogen Use Efficiency: Transport Solution in Rice Variations.

28.   201621-2, Viena, Austria, Plant Genetics and Breeding Technologies II, Keynote Speaker, Molecular Module-based Designer Breeding: From Theory to Practice.

29.   2016316-18, Royal Tulip Hotel, Shanghai, The CAS-JIC Centre of Excellence for Plant and Microbial Science (CEPAMS) Symposium2016, 特邀报告,Transport Solution for NUE Improvement in Rice.

30.   201658-11, 山东青岛青岛鑫复盛逸海国际酒店, 第二届中国植物逆境生物学学术研讨会(2016年), 特邀报告, Improvement ofnitrogen use efficiency: From biotechnology point of view.

31.   2016527, Shanghai, China. the TIPI Science Dayat Biofach 2016 Shanghai, 特邀报告: Green Agriculture: Driving Innovations in Crop Breeding.

32.   201665-10, Annapolis, Maryland, USA. International Workshop on Plant Membrane Biology (IWPMB) , 特邀报告, Transport solution for nitrogen use efficiency improvement in rice.

33.   2016610, University of Maryland, Washington DC, USA. 邀请报告, Rice Genetics: From Mechanisms to Breeding.

34.   2016630-7月2日, 广州, Sino-USA Chinese Collaborative Workshop--Opportunities and Challenges in Synthetic Biology, 特邀报告, Transport solution fornitrogen use efficiency improvement in rice.

35.   2016814-19, 北京. 7th International Crop Science Congress, Session chair, 特邀报告, Transport solution for nitrogen use efficiency improvement in rice.

36.   2016822-26, Montpellier, France. Nitrogen Nutrition of Plants (Nitrogen2016), 特邀报告, Improvement of Nitrogen Use Efficiency in Rice: Theory and Practice.

37.   2016111-3, 北京. 2016 World Life Science Conference (2016WLSC),特邀报告, Improvement of Nitrogen Use Efficiency in Rice: Theory and Practice.

1.   Wu J, Yang R, Yang Z, Zhao S, Yao S, Wang Y, Li P, Song X, Jin L, Zhou T, Xie L, Zhou X, Chu C, Qi Y, Cao X, and Li Y (2016) ROS Accumulation and Antiviral Defence Controlin Rice by MicroRNA528. Nat. Plants. 3: 16203.

2.       Li H, Hu B, Wang W, Zhang Z, Liang Y, Gao X, Li P, Liu Y, Zhang L, and Chu C (2016) Identification of microRNAs in rice root in response to nitrate and ammonium. J. Genet. Genomics 43: 651-661.

3.       Liu Y, Mao C, Chu C (2016) Research progress on functional genomics of rice nutrient utilization.  Chin. Bull. Life Sci. 28(10): 1230-1242.

4.       Guo Q, Wu F, Pang S, Zhao X, Chen L, Liu J, Xue B, Xu G, Li L, Jing H, and Chu C (2016) Crop 3D: a platform based on LiDAR for 3D high-throughput crop phenotyping. Sci. Sin. Vitae 46(10): 1210-1221.

5.    Liu Y, Hu B, and Chu C (2016) 15N-nitrate uptake activity and root-to-shoot transport assay. Bio-protocol. 6(16): e1897.

6.       Wang Y, Liang C, Wu S, Zhang X, Tang J, Jian G, Jiao G, Li F, and Chu C (2016) Significant Improvement of Cotton Verticillium Wilt Resistance by Manipulating the Expression of Gastrodia Antifungal Proteins. Mol. Plant 9(10): 1436-1439.

7.       Qu M, Hamdani S, Li W, Wang S, Tang J, Chen Z, Song Q, Li M, Zhao H, Chang T, Chu C, and Zhu X (2016) Rapid stomatal response to fluctuating light: an under-explored mechanism to improve drought tolerance in rice. Funct. Plant Biol. 43(8): 727-738.

8.       Wang H, Xu X, Vieira FG, Xiao Y, Li Z, Wang J, Nielsen R, and Chu C (2016) The power of inbreeding: NGS based GWAS of rice reveals convergent evolution during rice domestication. Mol. Plant 9(7): 975-985.

Cover Story. Featured in Molecular Plant  by Xuehui Huang (2016) From Genetic Mapping to Molecular Breeding: Genomics Have Paved the Highway. 9(7): 959-960.

9.       Tong H and Chu C (2016) Brassinosteroid regulates gibberellin synthesis to promote cell elongation in rice: Critical comments on Ross and Quittenden’s letter. Plant Cell 28(4): 833-835.

10.   Gao S, Fang J, Xu F, Wang W, and Chu C (2016)Rice HOX12 regulates panicle exsertion by directly modulating the expression of ELONGATEDUPPERMOST INTERNODE1. Plant Cell 28(3): 680-695.

Highlighted with Science News on April1, 2016 by Jennifer A. Lockhart: Feedingthe World: Uncovering a Key Regulator of Flower Head Development in Rice.

11.   Song Q, Chu C, Parry M, and Zhu XG (2016) Genetics-based dynamic systems model of canopy photosynthesis: The key toimprove light and resource use efficiencies for crops. Food Energy Security. 5(1): 18-25.

12.   Che R, Tong H, Shi B, Liu Y, Fang S, Liu D, Xiao Y, Hu B, Liu L, Wang H, Zhao M, and Chu C (2015) Control of grain size and rice yield by GL2-mediated brassinosteroid responses. Nat. Plants 2: 15195.

Featured with News and Views in Nature Plants by Hirokazu Tsukaya (2015):Yield Increase: GRFs Provide the Key. 2: 15210.

Highlighted in Chinese Bulletin of Botany by Lingtong Liu and Tai Wang (2016): miR396-GRF Modules: A New Prospective on Rice Molecular Breeding. 51: 148-151.

13.   Chu C (2015) A new era for crop improvement – From model-guided rationale design to practical engineering. Mol. Plant 8(9): 1299-1301.

14.   Liu L^,Tong H^,Xiao Y, Che R, Xu F, Hu B, Liang C, Chu J, Li J, and Chu C (2015) Activation of Big Grain1 significantly improves grain size by regulating auxin transport in rice. Proc. Natl. Acad. Sci. USA 112(35): 11102-11107.

15.   Li X, Liu H, Wang M, Liu H, Tian X, Zhou W,Lv T, Wang Z, Chu C,Fang J and Bu Q (2015)Combinations of four heading date genes determine rice adaptability to Heilongjiang province, northern limit of China. J. Integr. Plant Biol. 57(8): 698-707.

16.   Hu B, Wang W, Ou S, Tang J, Li H, Che R, Zhang Z, Chai X, Wang H, Wang Y, Liang C, Liu L, Piao Z, Deng Q, Deng K, Xu C, Liang Y, Zhang L, Li L, and Chu C (2015) Variation in NRT1.1B contributes to nitrate-use divergence between rice subspecies. Nat. Genet. 47(7): 834-838.

Featured with News and Views in Nature Plants by Dai-Yin Chao & Hong-Xuan Lin (2015) Nitrogen-use efficiency: Transport solutionin rice variations. 1: 15096.

Highlighted with a Research Highlight article in J. Genet. Genomics. 2015, 42(9): 463-465 and Sci. China Life Sci. 2015, 58(8): 827-828.

Selected for F1000 Prime. doi:10.3410/f.725540326.793508312.

17.   Liang C, Zheng G, Li W, Wang Y, Hu B, Wang H, Wu H, Qian Y, Zhu XG, Tan DX, Chen SY, and Chu C (2015) Melatonin delays leaf senescence and enhances salt stress tolerance in rice. J. Pineal Res. 59(1): 91-101.

18.   Wang W, Zhang L, LiH, Zhang Z, Hu B, and Chu C (2015) Recent progress in molecular dissection of nutrient uptake and transport in rice. Sci. Sin. Vitae 45(6): 569-590.

19.   Chen J, Liu X, Wang C,Yin SS, Li XL, Hu WJ, Simon M, Shen ZJ, Xiao Q, Chu CC, Peng XX, and Zheng HL (2015) Nitric oxide ameliorates zinc oxide nanoparticles-induced phytotoxicity in rice seedlings. J. Hazard. Mater. 297: 173-182.

20.   Xue Y, Chong K, HanB, Gui J, Wang T, Fu X, He Z, Chu C,Tian Z, Cheng Z, and LinS (2015) A new chapter of designer breeding in China: An update on the strategic program of molecular module-based designer breeding systems. Bull. Chin. Acad. Sci. 30(3): 262-271.

21.   Yin CC, Ma B, Collinge D, Pogson B, He SJ, Xiong Q, Duan KX, Chen H, Yang C, Lu X, Wang YQ, Zhang WK, Chu CC, Sun XH, Fang S, Chu JF, Lu TG, Chen SY, and Zhang JS (2015) Differential regulation of ethylene responses in roots and coleoptiles by a carotenoid isomerase MHZ5-mediated abscisic acid pathway in rice. Plant Cell 27(4): 1061-1081.

22. Liang C and Chu C (2015) Towards understanding abscisic acid-mediated leaf senescence. Sci. China Life Sci. 58(5): 506-508.

23.    Hu B, Wang W, Deng K, Li H, Zhang Z, Zhang L, and Chu C (2015) microRNA399 is involved in multiple nutrient responses in rice. Front. Plant Sci. 6: 188.

24.   Hamdani S, Qu M, Xin C, Chu C, Govindjee G, and Zhu X (2015) Variations of photosynthetic parameters in Chinese elite rice revealed by simultaneous measurements of Chlorophyll a fluorescence induction and 820nm transmission signal. J. Plant Physiol. 177: 128-138.

25.   Xu F, Fang J, Ou S, Gao S, Zhang F, Du L, Xiao Y, Wang H, Sun X, Chu J, Wang G, and Chu C (2015)Variations in CYP78A13 coding region influence grain size and yield in rice. Plant Cell Environ. 38(4): 800-811.

26.   Tong H, Xiao Y, Liu D, Gao S, Liu L, Yin Y, Jin Y, Qian Q, and Chu C (2014) Brassinosteroid regulates cell elongation by modulating gibberellin metabolismin rice. Plant Cell 26(11): 4376-4393.

Featured with In Brief in Plant Cell by Nancy R. Hofmann (2015). Taking Hormone Crosstalk to a New Level: Brassinosteroids Regulate Gibberellin Biosynthesis. Plant Cell 25(8): 2081.

27.    SunC, Chen D, Fang J, Wang P, Deng X, and Chu C (2014) Understanding the genetic and epigenetic architecture in complex network of rice flowering pathways. Protein Cell 5(12): 889-898.

28.   Liu Y, Fang J, Xu F, Chu J, Yan C, Schläppi M, Wang Y, and Chu C (2014)Expression patterns of ABA and GA metabolism genes and hormone levels during rice seed development and imbibition: A comparison of dormant and non-dormantrice cultivars. J. Genet. Genomics 41(6): 327-338.

29.   Liang C, Wang Y, Zhu Y, Tang J, Hu B, Liu L, Ou S, Wu H, Sun X, Chu J, and Chu C (2014) OsNAP connects absisic acid and leaf senescence by fine tuning absisic acid biosynthesis and directly targeting senescence-associated genes in rice. Proc. Natl. Acad. Sci. USA 111(27): 10013-10018.

30.   Gao S, Fang J, Xu F, Wang W, Sun X, Chu J, Cai B, Feng Y, and Chu C (2014) CYTOKININ OXIDASE/DEHYDROGENASE4 integrates cytokinin and auxin signaling to control rice crown root formation. Plant Physiol. 165(3): 1035-1046.

31.    Zhang L, Hu B, Li W, Che R, Deng K, Li H, Yu F, Ling H, Li Y, and Chu C (2014)OsPT2, a phosphate transporter, is involved in active uptake of selenite inrice. New Phytol. 201(4): 1183-1191.

32.   Liu C, Mao B, Ou S, Wang W, Liu L, Wu Y, Chu C*, and Wang X* (2014) OsbZIP71, a bZIP transcription factor, confers salinity and drought tolerance in rice. Plant Mol. Biol., 84(1-2): 19-36. (*Corresponding authors)

33.    Su L, Li A, Li H, Chu C, and Qiu JL (2013) Direct modulation of protein level in Arabidopsis. Mol.Plant 6(5): 1711-1714.

34.   Fan Y, Du K, Gao Y, Kong Y, Chu C, Sokolov V, and Wang Y (2013)Transformation of LTP gene into Brassica napus to enhance its resistance to Sclerotinia sclerotiorum. Russ. J. Genet. 49(4): 380-387.

35.   Wang Y, Lin A, Loake GJ, and Chu C (2013) H2O2-induced leaf cell death and the crosstalk of reactive nitric/oxygen species. J. Integr. Plant Biol. 55(3): 202-208.

36.    Wang Y, Loake GJ, and Chu C (2013) Cross-talk of nitric oxide and reactive oxygen species in plant programed cell death. Front. Plant Sci. 4: 314.

37.   Guo X, Hou X, Fang J, Wei P, Xu B, Chen M, Feng Y, and Chu C (2013) The rice GERMINATION DEFECTIVE1, encoding a B3 domain transcriptional repressor, regulates seed germination and seedling development by integrating GA and carbohydrate metabolism. Plant J. 75(3): 403-416.

38.   Wang L, Song X, Gu L, Li X, Cao S, Chu C,Cui X, Chen X, and Cao X (2013) NOT2 proteins promote Pol II-dependent transcription and interact with multiple miRNA biogenesis factors in Arabidopsis. Plant Cell 25(2): 715-727.

39.   Sun C, Fang J, Zhao T, Xu B, Zhang F, Liu L, Tang J, Zhang G, Deng X, Chen F, Qian Q, Cao X, and Chu C (2012) The histone methyltransferase SDG724 mediates H3K36me2/3 deposition at MADS50 and RFT1, and promotes flowering in rice. Plant Cell 24(8): 3235-3247.

40.    Tong H, Liu L, Jin Y, Du L,Yin Y, Qian Q, Zhu L, and Chu C (2012) DWARF AND LOW-TILLERING acts as a direct downstream target of a GSK3/SHAGGY-like kinase to mediate brassinosteroid responses in rice. Plant Cell 24(6): 2562–2577.

41.   Wu HJ, Zhang Z, Wang JY, Oh DH, Dassanayake M, Liu B, Huang Q, SunHX, Xia R, Wu Y, Wang Y, Yang Z, Liu Y, Zhang W, Zhang H, Chu J, Yan C, Fang S, Zhang J, Wang Y, Zhang F, Wang G, Lee SY, Cheeseman JM, Yang B, Li B, Min J, Yang L, Wang J*, Chu C*, Chen SY*, Bohnert HJ*, Zhu J-K*, Wang XJ*, and Xie Q* (2012) Insights into salt tolerance from the genome of Thellungiella salsuginea. Proc. Natl. Acad. Sci. USA 109(30): 12219-12224.

Highlighted with Research Highlights in Nature Middle East on July 12, 2012 by Moheb Costandi: “Genome sequencing reveals a plant's adaptation to extreme conditions”.

42.   Song X, Wang D, Ma L, Chen Z, Li P, Cui X, Liu C, Cao S, Chu C, Tao Y, and Cao X (2012) Rice RNA-dependent RNA polymerase 6 acts in small RNA biogenesis and spikelet development. Plant J. 71(3): 378-389.

43.   Song X, Li P, Zhai J, Zhou M, Ma L, Liu B, Jeong DH, Nakano M, Cao S, Liu C, Chu C, Wang XJ, Green PJ, Meyers BC, and Cao X (2012) Roles of DCL4 and DCL3b in rice phased small RNA biogenesis. Plant J. 69(3): 462-474.

44.    Wu H, Chen C, Du J, Liu H, Yan C, ZhangY, He Y, Wang Y, Chu C, Feng Z, Li J, and Ling HQ (2012) Co-overexpression FIT with AtbHLH38 or AtbHLH39 in Arabidopsis enhanced cadmium tolerance via increased cadmium sequestration in roots and improved iron homeostasis of shoots. Plant Physiol. 158(2): 790-800.

45.    Tong H and Chu C (2012) Brassinosteroid signaling and application in rice. J. Genet. Genomics 39(1): 3-9.

46.    LiuX^, Li F^, Tang J, Wang W, Zhang F, Wang G, Chu J,Yan C, Wang T, Chu C*, and Li C* (2012) Activation of the jasmonic acid pathway by depletion of the hydroperoxide lyase OsHPL3 reveals crosstalk betweenthe HPL and AOS branches of the oxylipin pathway in rice. PLoS One 7(11): e50089 (*Corresponding author).

47.   Shen H, Liu C, Zhang Y, Meng X, Zhou X, Chu C, and Wang X. (2012) OsWRKY30 is activated by MAP kinases to confer drought tolerance in rice. Plant Mol. Biol. 80(3): 241-253.

48.    Lin A^, Wang Y^,Tang J^, Xue P, Li C, Liu L, Hu B, Yang F, Loake GJ, and Chu C (2012) Nitric oxide and proteins-nitrosylation are integral to hydrogen peroxide induced leaf cell death inrice. Plant Physiol. 158: 451-464 (^co-first authors).

49.    Wang H, Fang J, Liang C, He M, Li Q, and Chu C (2011) Computation-assisted SiteFinding-PCR for isolating flanking sequence tags in rice. BioTechniques 51: 421-423.

50.   JinY^, Luo Q^,Tong H^,Wang A, Cheng Z, Tang J, Li D, Zhao X, Li X, Wan J, Chu C, and Zhu L (2011) An AT-hook gene is required for palea formation and floral organ number control in rice. Dev. Biol. 359: 277-288. (^co-firstauthors)

51.   Yang Z and Chu C (2011) Towards understanding plant response to heavy metal stress. In: Abiotic Stress in Plants - Mechanisms and Adaptations, Venkateswarlu B and Shanker AK (Ed.), p59-78.

52.   Kong F, Mao S J, Du K, Wu M, Zhou X, Chu C, and Wang Y (2011) Comparative proteomics analysis of OsNAS1 transgenic Brassica napus under salt stress. Chin. Sci. Bull. 2011, 56(22): 2343-2350.

53.   Li C, Wang Y, Liu L, Hu Y, Zhang F, Sodmergen, Wang G, Schläppi MR, and Chu C (2011) A rice plastidial nucleotide sugar epimerase is involved in galactolipid biosynthesis and improves photosynthetic efficiency. PLoS Genet. 7(7): e1002196.

54.   Feng J, Cao L, Li J, Duan C, Luo X, Le N, Wei H, Liang S, Chu C, Pan Q, and Tang JL (2011) Involvement of OsNPR1/NH1 in ricebasal resistance to rice blast fungus Magnaporthe oryzae. Eur. J. Plant Pathol. 131(2): 221-235.

55.   Kong F, Mao S J, Du K, Wu M, Zhou X, Chu C, and Wang Y (2011)Comparative proteomics analysis of OsNAS1 transgenic Brassica napus under salt stress. Chin. Sci. Bull. 56: 2343-2350.

56.   Meng X, Qin J, Wang L,Duan G, Sun G, Wu H, Chu C,Ling HQ, Rosen B, and Zhu Y (2011) Arsenic biotransformation and volatilization in transgenic rice. New Phytol. 191: 49-56.

57.    Tang J, Zhu X, Wang Y, Liu L, Xu B, Li F, Fang J, and Chu C (2011) Semidominant mutations in the CC-NB-LRR-type R gene, NLS1, lead to constitutive activation of defense responses in rice. Plant J. 66: 996-1007.

58.    Gao T, Wu Y, Zhang Y, Liu L, Ning Y, Wang D, Tong H, Chen S, Chu C, and Xie Q (2011) OsSDIR1 overexpression greatly improves drought tolerance in transgenic rice. Plant Mol. Biol. 76: 145-156.

59.    Hu B and Chu C (2011) Phosphate starvation signaling in rice. Plant Sig. Behav. 6(7): 927-929.

60.    Hu B, Zhu C, Li F, Tang J, Wang Y,Lin A, Liu L, Che R, and Chu C(2011) LEAF TIP NECROSIS1 plays a pivotal role in regulation of multiple phosphate starvation responses in rice. Plant Physiol. 156: 1101-1115.

61.    Wu X, Zuo S, Chen Z, Zhang Y, Zhu J, Ma N, Tang J, Chu C, and Pan X (2011) Fine mapping of qSTV11TQ, a major gene conferring resistance to rice stripe disease. Theor. Appl. Genet. 122(5): 915-923.

62.   Sun C^,Liu L^, Tang J, LinA, Zhang F, Fang J, Zhang G, and Chu C (2011) RLIN1, encoding a putative coproporphyrinogen III oxidase, is involved in lesion initiation in rice. J. Genet. Genomics 38(1): 29-37 (^co-first authors).

63.   Chai C^, Fang J^, Liu Y, Tong H, Gong Y, Wang Y, Liu M, Wang Y, Qian Q, Cheng Z, and Chu C (2011) ZEBRA2, encoding a carotenoid isomerase, is involved in photoprotection in rice. Plant Mol.Biol. 75(3): 211-221.

64.   Qin X, Liu Y, Mao S, Li T, Wu H, Chu C, and Wang Y (2011) Genetic transformation of lipid transfer protein encoding gene in Phalaenopsis amabilis to enhance cold resistance. Euphytica 177: 33-43.

65.   Zhang S, Li G, Fang J, Chen W, Jiang H, Zou J, Liu X, Zhao X, Li X, Chu C, Xie Q, Jiang X, and Zhu L (2010) The interactions among DWARF10, auxin and cytokinin underlie lateral bud outgrowth in rice.  J. Integr. Plant Biol. 52(7): 626-638.

66.   Li F^, Liu W^, Tang J, Chen J, Tong H, Hu B, Li C, Fang J, Chen M, and Chu C (2010) Rice DENSE AND ERECT PANICLE 2 is essential for determining panicle outgrowth and elongation. Cell Res. 20: 838-849.

67.   Chen H, Zhang Z, Teng K, Lai J, Zhang Y, Huang Y, Li Y, Liang L, Wang Y, Chu C, Guo H, and Xie Q (2010) Up-regulation of LSB1/GDU3 impacts geminivirus infection by activating the salicylic acid pathway. Plant J. 62(1): 12-23.

68.   Wang Y, Chen C, Loake G, and Chu C (2010) Nitric oxide: Promoter or suppressor of programmed cell death? Protein Cell 1(2): 133-142.

69.   Spadaro D, Yun BW, Spoel SH, Chu C, Wang Y, and Loake G (2010)The redox switch: dynamic regulation of protein function by cysteine modifications. Physiol. Plant. 138(4): 360-371.

70.   Tong H and Chu C (2009) Roles of DLT in fine modulation on brassinosteroid response in rice. Plant Sig. Behav. 4 (5): 438 - 439.

71.   Tong H, Jin Y, Liu W, Li F, Fang J, Yin Y, Qian Q, Zhu L, and Chu C (2009) DWARF AND LOW-TILLERING, a new member of GRAS family, plays positive roles in brassinosteroid signaling in rice. Plant J. 58: 803-816.

72.   Ma Y, Liu L, Zhu C, Sun C, Xu B, Fang F, Tang J, Luo A, Cao S, Li G, Qian Q, Xue Y, and Chu C (2009) Molecular analysis of rice plants harboring a multi-functional T-DNA tagging system. J. Genet. Genomics 36(5): 267-276.

73.    Huang X, Qian Q, Liu Z, Sun H, He S, Luo D, Xia G, Chu C, Li J, and Fu X (2009) Natural variation at the DEP1 locus enhances grain yield in rice. Nat. Genet. 41(4): 494-497.

74.   Wang Y, Feechan A, Yun BW, Shafiei R, Hofmann A, Taylor P, Xue P, Yang F, Xie Z, Pallas JA, Chu C, and Loake G (2009) S-nitrosylation of AtSABP3 antagonizes the expression of plant immunity. J. Biol. Chem. 284: 2131-2137.

75.   Guo X, Wu Y, Wang Y, and Chu C (2009) OsMSRA4.1 and OsMSRB1.1, two rice plastidial methionine sulfoxide reductases, are involved in abiotic stress responses. Planta 230: 227-238.

76.    Yang Z, Wu Y, Li Y, Ling HQ, and Chu C (2009) OsMT1a, a type 1 metallothionein, plays the pivotal role in zinc homeostasis and drought tolerance in rice. Plant Mol. Biol. 70(1-2): 219-229.

77.   Wang Q, Guan Y, Wu Y, Chen H, Chen F, and Chu C (2008) Overexpression of a rice OsDREB1F gene increases salt, drought, and low temperature tolerance in both Arabidopsis and rice. Plant Mol. Biol. 67:589-602.

78.    Zhang Y, Li Y, Gao T, Zhu H, Wang D, Zhang H, Ning Y, Liu L, Wu Y, Chu C,Guo H, and Xie Q (2008) Arabidopsis SDIR1 enhances drought tolerance in crop plants. Biosci. Biotech. Biochem. 72: 2251-2254.

79.    Fang J and Chu C(2008) Abscisic acid and the pre-harvest sprouting in cereals. Plant Sig. Behav. 3: 1046-1048.

80.   Fang J^, Chai C^, Qian Q^, Li C, Tang J, Sun L, Huang Z, Guo X, Sun C, Liu M, Zhang Y, Lu Q, Wang Y, Lu C, Han B, Chen F, Cheng Z, and Chu C (2008) Mutations of genes in synthesis of the carotenoid precursors of ABA lead to preharvest sprouting and photo-oxidation in rice. Plant J. 54: 177-189.

81.    Bai X, Wang Q, and Chu C (2008) Excision of a selective marker in transgenic rice using a novel Cre/loxP system controlled by a floral specific promoter. Transgenic Res. 17: 1035-1043.

82.   Qi J, Qian Q, Bu Q, Li S,Chen Q, Sun J, Liang W, Zhou Y, Chu C, Li X, Ren F, Palme K, Zhao B, Chen J, Chen M, and Li C (2008) Mutation of therice NARROW LEAF1 gene, which encodes a novel protein, affects vein patterning and polar auxin transport. Plant Physiol. 147: 1947-1959.

83.    Hong JK, Yun BW, Kang JG, Raja MU, Kwon E, Sorhagen K, Chu C, Wang Y, and Loake GJ (2008) Nitric oxide function and signalling in plant disease resistance. J. Exp. Bot. 59: 147-154.

84.   Liu X, Bai X, Wang X, and Chu C (2007) OsWRKY71, a rice transcription factor, is involved in rice defense response. J. Plant Physiol. 164: 969-979.

85.    Dong H, Deng Y, Mu J, Lu Q, Wang Y, Xu Y, Chu C, Chong K, Lu C, and Zuo J (2007) The Arabidopsis Spontaneous Cell Death1 gene, encoding a ζ-carotene desaturase essential for carotenoid biosynthesis, is involved in photoprotection, chloroplast development and retrograde signaling. Cell Res. 17: 458-470.

86.    Liu B, Chen Z, Song X, LiuC, Cui X, Zhao X, Fang J, Xu W, Zhang H, Wang X, Chu C, Deng XW, Xue Y, and Cao X (2007) Oryza sativa Dicer-like4 reveals a key role for small interfering RNA silencing in plant development. Plant Cell 19: 2705-2718.

87.    Ding Y, Wang X, Su L, ZhaiJ, Cao S, Zhang D, Liu C, Bi YP, Qian Q, Cheng ZK, Chu C*, and Cao X*(2007) SDG714, ahistone H3K9 methyltransferase, is involved in Tos17 DNA methylation and transposition in rice. Plant Cell 19: 9-22 (*Corresponding author).

Featured with Leading Edge -Molecular Biology Select in  Cell  by Priya Prakash Budde  (2007) Connecting the Dots between Histone Methylation and DNA Methylation.128(4): 633.

88.   Zhang K, Qian Q, Huang Z, Wang Y, Li M, Hong L, Zheng D, Gu M, Chu C, and Cheng Z (2006) GOLDHULL AND INTERNODE2 (GH2) encodesa primarily multifunctional cinnamyl-alcohol dehydrogenase (CAD) in Oryza sativa. Plant Physiol. 140: 972-983.

89.   Xiong G, Hu X, Jiao Y, YuY, Chu C, Li J, Qian Q, and Wang Y (2006) LEAFY HEAD2, which encodes a putative RNA-binding protein, regulates shoot development of rice. Cell Res. 16: 267-276.

90.    Luo A^, Qian Q^, Ying H^, Liu X, Yin C, Lan Y, TangJ, Tang Z, Cao S,Wang X, Xia K, Fu X, Luo D, and Chu C (2006) EUI1, encoding a putative cytochrome P450 monooxygenase, regulates the internodes elongation by modulating GA responses in rice. Plant Cell Physiol. 47: 181-191. (^co-first authors)

91.   Zhou H, He S, Cao Y, Chen T, Du B, Chu C, Zhang J, and Chen S (2006) OsGLU1, A putative membrane-bound endo-1,4-b-D-glucanase from rice, affects plant internode elongation. Plant Mol. Biol. 60: 137-151.

92.   Wu Y, Wang Q, Ma Y, and Chu C (2005) Isolation and expression analysis of salt up-regulated ESTs in upland rice using PCR-based subtractive suppression hybridization method. Plant Sci. 168: 847-853.

93.   Luo A, Liu L, Tang Z, Bai X, Cao S, and Chu C (2005) Down-regulation of OsGRF1 gene in rice rhd1 mutant results in reduced heading date. J. Integr. Plant Biol. 47: 745-752.

94.   Liu X, Bai X, Qian Q, Wang X, Chen M, and Chu C (2005) OsWRKY03, a rice transcription activator that functions in defense signaling pathway upstream ofOsNPR1. Cell Res. 15: 593-603.

95.   Liu B, Li P, Li X, Liu C, Cao S, Chu C, and Cao X (2005) Loss of function of OsDCL1 affects microRNA accumulation and causes developmental defects in rice. Plant Physiol. 139: 296-305.

96.   Si L, Cao S, and Chu C (2003) Isolation of a 1195 bp 5’-flanking region of rice cytosolic fructose-1,6-bisphosphatase and analysis of its expression in transgenic rice. Acta Bot. Sin. 45: 359-364.

97.   Junker BH, Chu C, Sonnewald U, Willmitzer L, and Fernie AR (2003) In plants the alc gene expression system responds more rapidly following induction with acetaldehyde than with ethanol. FEBS Lett. 535 (1-3): 136-140.

98.   Sweetman JP, Chu C, Qu N, Greenland AJ, Sonnewald U, and Jepson I (2002) Ethanol vapor is an efficient inducer of the alc gene expression system in model and crop plant species. Plant Physiol. 129: 943-948.

99.   Si L, Wang L, Cao S, and Chu C (2002) Deletion of a 93 bp 5’ flanking region of rice cytosolic fructose-1,6-bisphosphatase completely altered its expression pattern. Acta Bot. Sin. 44: 1339-1345.

100. Chen S, Qu N, Cao S, Bauwe H, Chen S, Tian W, and Chu C (2001) Expression pattern of gdcsP promoter from C3-C4 intermediate plant Flaveria anomala in transgenic rice. Chin. Sci. Bull. 46 (19): 1635-1638.

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